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Granule cell dispersion
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Granule cell dispersion : ウィキペディア英語版
Granule cell dispersion

Granule cell dispersion is one of the abnormal structure that was shown in the patients' brain of temporal lobe epilepsy. It is also shown in different kind of animal model, such as kainic acid model, pilocarpine model, kindling model. But granule cell dispersion was not found by using perforant pathway stimulation.
It was first described by Houser. In a normal situation, the granule cell in dentate gyrus should be tightly packed. But in granule cell dispersion, the compact formation was lost, and the axons need to extend longer to reach the neighboring granule cells.
==Mechanism of formation==
There are currently two hypothesis mechanism. First, it might be a consequence of a migration disorder, the initial injury that release toxic that affect the normal migration of granule cells.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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